MARVEL CINEMATIC UNIVERSE
Worldwide gross: $18,263,221,776
Though it seems a bit unfair, the whole of the Marvel Cinematic Universe—including The Avengers, Iron Man, Captain America, and the Guardians of the Galaxy movies—is officially a single franchise in Hollywood's eyes. Which makes it a tough one to beat, with 28 films (and counting) in the past 12 years, led (financially-speaking) by Avengers: Infinity War ($2,048,797,682), The Avengers ($1,517,935,897), Avengers: Age of Ultron ($1,403,013,963), and Black Panther ($1,348,258,224).