Michael Spinks in 1985
Holmes won his first 48 professional bouts, including victories over Norton, Ali, Earnie Shavers, Mike Weaver, Gerry Cooney, Tim Witherspoon, Carl Williams and Marvis Frazier, and falling one short of matching Rocky Marciano's career record of 49–0 when he lost to Michael Spinks in 1985. Holmes retired after losing a rematch to Spinks the following year, but made repeated comebacks. He was unsuccessful in three further attempts (against Mike Tyson, Evander Holyfield and Oliver McCall) to regain the heavyweight title, the last in 1995.