Java Script and VB Script are both scripting languages that programmers use as tools to develop applications for personal computers. But VB Script is more Microsoft-centric both in its orientation and its operability.
Wikipedia Definition
"JavaScript is an object-oriented scripting language used to enable programmatic access to objects within both the client application and other applications. ... JavaScript was influenced by many languages and was designed to look like Java, but to be easier for non-programmers to work with."
"VBScript (short for Visual Basic Scripting Edition) is an Active Scripting language, developed by Microsoft, which uses the Component Object Model to access elements of the environment within which it is running.... The language's syntax reflects its origins as a limited variation of Microsoft's Visual Basicprogramming language."