Setting up the X2 This function is used to exchange necessary data for the eNB for setup the X2 interface and implicitly perform an X2 Reset.
Elementary Procedure
a) X2 Setup
eNB Configuration Update This function allows updating of application level data needed for two eNBs to inter-operate correctly over the X2 interface.
Elementary Procedures
a) eNB Configuration Update
b) Cell Activation
In short you first make x2 setup and then exchange eNB config update.
Read more at: http://tech.queryhome.com/48522/x2ap-protocol-in-lte