On behalf of Bart:
To signal that SGs Application is not reachable.
When it's down then it's very good to check why, unless you don't care if subscribers can be located for use of CS-services.
What I would do is I would check the protocol stack and stars debugging from the top to bottom. There might be wrong config on SGsAP, or problem on SCTP lvl (are cookies exchanged?), then IP, later VLANs or.. Physical connection is down. Maybe even VXLANs if used - layer 2 over layer 3. Basically same procedure as with any other case.
In general problem is in 3 places. MME, connection between or on MSC/VLR pair end.