All the preamble sequences should be orthogonal to each other. Otherwise, various preambles from multiple UEs within the same cell can interfere each other. So we have to shift the generated sequence by a specifically designed value and this value is called Cv (Cyclic Shift Value) and it is defined as follows.
First, you would notice that we use different process to calculate Cv depending on whether we use 'unrestricted sets' or 'restricted sets'. This decision is made by 'Highspeedflag' information elements in SIB2. If Highspeedflag is set to be TRUE, we have to use 'restricted sets' and if Highspeedflag is false, we have to use 'unrestricted sets'.
Hope this clarifies the doubt and usage of highspeed flag in prach.
Source: http://www.sharetechnote.com/html/RACH_LTE.html