Access network only provides the last mile (dont take in literal terms) connection while ENB to PGW is the mobile network, which can connect two mobile like they are in a circle (loosely saying).
In general other then Uu interface all interfaces are wired but it is not necessary it can be anything including the wireless only stuff is the network should expose IP interface.
Now coming to your last portion, as I said mobile network is a circle only call is taken care from one circle to another circle by NLD (national long distance carrier) or to another country by an ILD (International Long distance carreir).
Lets take the example one UE from Bangalore makes a call to another UE in Bihar, call originates from UE-->eNodeB-->SGW-->PGW from here it is handed over to an NLD which takes the call to Bihar and give it to PGW (I have assumed all IP case here otherwise it would be MSC-GMSC in place of SGW-PGW)